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Cd40 ligand

CD154 - Wikipedi

antitumor functions of macrophages activated by CD40

Cluster of differentiation 40, CD40 is a costimulatory protein found on antigen-presenting cells and is required for their activation. The binding of CD154 on T H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. Deficiency can cause Hyper-IgM syndrome type 3. Function. The protein receptor encoded by this gene is a member of the TNF-receptor. L'absence d'expression du ligand CD40 sur les lymphocytes T activés est caractéristique de la maladie. Le diagnostic final du syndrome hyper-IgM lié à l'X repose sur l'identification de la mutation dans le gène codant pour le ligand de CD40 In human, CD40 is coded by TNFRSF5 gene and has 7 transcripts. Its ligand, CD154 (CD40L), is a protein that is primarily expressed on activated T cells and is also a member of the TNF superfamily of molecules - Accueil , Pétanque et Jeu Provençal, CD 40, SOUSTONS, 40140, modifié le : 3/1/202

CD40-CD40 ligand. CD40 is a cell surface receptor that belongs to the tumor necrosis factor-R (TNF-R) family, and that was first identified and functionally characterized on B lymphocytes. Its critical role in T cell-dependent humoral immune responses was demonstrated by patients with the hyper-IgM syndrome, as well CD40 Ligand, also known as TNFSF5, CD154, TRAP, and gp39, is a trimeric protein that is expressed in transmembrane and soluble forms. It is expressed by many immune cell types as well as by endothelial and smooth muscle cells of the vasculature. It binds to CD40 on antigen presenting cells, platelets, and endothelial and epithelial cells, leading. CD40 ligand (CD40L)/CD40 interactions play a central role in T-cell-dependent B-cell activation as previously shown by in vitro studies, the phenotype of CD40L knockout mice and the defective expression of CD40L in patients who have X-linked immunodeficiency with hyper-IgM

CD40 Ligand - an overview ScienceDirect Topic

CD40 ligand (CD40L) is a type II transmembrane protein that belongs to the tumor necrosis factor gene superfamily and is mainly expressed on activated T cells and platelets. On T cells that have been stimulated through their T cell receptor (TCR) and co-stimulatory ligands such as CD28, preformed CD40L is upregulated within minutes on the cell surface and reaches peak levels after 6 h, and. Anti-CD40-ligand mAb reagents interfere with the interaction of T-cell CD40L with B-cell CD40, thereby blocking costimulatory signals required for cognate T-cell help that promotes antigen-specific B-cell proliferative responses CD40 ligand attaches like a key in a lock to its receptor protein, CD40, which is located on the surface of immune system cells known as B cells. B cells are involved in the production of proteins called antibodies or immunoglobulins that help protect the body against infection. There are several classes of antibodies, and each one has a different function in the immune system. B cells are able to mature into the cells that produce immunoglobulin M (IgM) without any signals from other cells.

CD40 ligand, soluble form: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling Background: Strong evidence supports a role for CD40 ligand (CD40L) as marker and mediator of inflammatory diseases such as atherosclerosis. Despite extensive characterization of CD40, the classic receptor of CD40L, its role in immune defense against inflammatory diseases remains uncertain Abstract: CD40 is a cell surface receptor that belongs to the tumor necrosis factor-R (TNF-R) family, and that was first identified and functionally characterized on B lymphocytes CD40 is a cell surface receptor that belongs to the tumor necrosis factor‐R (TNF‐R) family, and that was first identified and functionally characterized on B lymphocytes. Its critical role in T cell‐dependent humoral immune responses was demonstrated by patients with the hyper‐IgM syndrome, as well as by gene targeting in mice

  1. ed by . activation assay. using enriched CD19 + B cells in the presence of the cross-linking antibody and of 50 IU/mL Interleukin 4. Activity of Human CD40-Ligand.
  2. The CD40 ligand molecule aids in stimulating B cells in the immune response. The CD40 molecule (109535) is a glycoprotein expressed on B lymphocytes, epithelial cells, and some carcinoma cells
  3. Soluble CD40 ligand levels according to the presence of atherosclerosis in different arterial territories. (a) in the whole sample, and (b) excluding patients with prior revascularization of the coronary and/or lower extremity arterial territories. Soluble CD40 ligand values are expressed as mean (standard deviation). sCD40L—soluble CD40 ligand
  4. Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933)

CD40 (protein) - Wikipedi

CD40 Ligand cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD40 Ligand of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector. CD40 Ligand qPCR Primer (3) Verified forward and reverse primers for analyzing. CD40 Ligand (CD40L), a member of the TNF family, was initially thought to be solely implicated in thymus-dependent humoral responses. However, work by several groups showed that CD40L plays a more global role in various systems. Recent evidence has outlined an important role for CD40L in the physiopathology of the vascular system. Indeed, by interacting with its principal receptor, CD40, or.

Syndrome d'hyper-IgM lié à l'X - IRI

Search results for CD40 ligand at Sigma-Aldrich. Species Human (959) , Species Mouse (21947) , Species Rat (84349) , Species domestic guinea pig (100733664) , Species naked mole-rat (101700616) , Species Zebrafish (793819) , Species cow (282387) , Species Horse (100054624) , Species domestic cat (493850) , Species dog (403468) , Species chicken (395485 CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines . CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma , TNF-alpha , and IL2 . Description. sCD40 Mouse. Cd40 ligandHigh Purity, Bioactivity validated in functional ELISA and/or FAC Inflammation regulates atherogenesis and soluble CD40 ligand (sCD40L) is an inflammatory mediator associated with the presence of single-territorial atherosclerosis

CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2 The research report on the CD40 Ligand Market studies every minute and trending aspect in the industry to offer actionable insights to business owners and stakeholders. The detailed information will help the buyers to plan profit-maximising strategies for the forecast period 2020 - 2026 CD40-CD40 ligand interaction in CD4+ T cell contact-dependent activation of monocyte interleukin-1 synthesis, European Journal of Immunology, vol. 24, no. 12, pp. 3148- 3154, 1994. [51] R. D. Stout and J. Suttles, The many roles of CD40 in cell-mediated inflammatory responses, Immunology Today, vol. 17, no. 10, pp. 487-492, 1996. [52] J. Suttles and R. D. Stout, Macrophage. CD40 Ligand Deficiency. Seren Hamsici. Description. This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The interaction of CD40 and CD40L on B and T cells, respectively, is crucial for B cell immunoglobulin class switching. Upon successful signaling. CD40 ligand (CD40L) is an inflammatory molecule of the tumor necrosis factor (TNF) superfamily originally identified on cells of the immune system. Interaction of CD40L with its respective receptor on B cells, CD40, is of critical importance for immunoglobulin isotype switching during the immune response

CD40 ligand (CD40L) is a member of the tumor necrosis factor (TNF) family of cell surface interaction molecules. It is mainly expressed in CD4 + T cells and interacts with CD40 on antigen-presenting cells to regulate both humoral and cellular immune responses. The CD40 cytoplasmic domain binds directly to several TNF receptor-associated factors (TRAFs), and this interaction is thought to. CD40-ligand is also known as CD154, the T cell-B cell activating molecule (T-BAM), TRAP or gp39. CD40-ligand is a member of the Tumor Necrosis Factor (TNF) Super Family. Other TNF Super Family. Le CD40 est une protéine de type cluster de différenciation intervenant dans la formation de l'athérome et dans certaines maladies inflammatoires. Son gène est CD40 porté par le chromosome 20 humain. Rôles. Il appartient à la famille des récepteurs au facteur de nécrose tumorale [3]. Son ligand externe est le CD40L [3]. Ses ligands internes (intracytoplasmiques) sont les TRAF2, TRAF3.

CD40/CD40L Signaling Pathway - Creative Diagnostic

IJMS | Free Full-Text | The Signaling Role of CD40 Ligand

CD 40 - Accuei

CD40-CD40 ligand - PubMe

CD40 Ligand/TNFSF5 Products: R&D System

The cells were stimulated for 24 h at 37°C with rhsCD40L (recombinant human soluble CD40 ligand; 1 μg/ml; Alexis Biochemicals, San Diego, CA). After culture, ∼30-50% of the islet cells remained alive, as assessed by dye exclusion. To identify intracellular pathways involved in CD40 signaling, the MEK1/2 phosphorylation inhibitor PD98059 (50 μmol/l; Cell Signaling Technology, Beverly, MA. ligand de CDXX ». Cest par exemple le cas du CD40-ligand, qui porte le nom standard de CD154.De même que pour les noms CD40 · CD44 · CD45 · CD47 · CD48 · CD50 · CD55 · CD56 · CD58 · CD59 · CD69 · CD73 · CD74 · CD84 · CD95 · CD117 · CD119 · CD123 Comment deviner que le ligand du CD27 est le CD70, et que les CD80 et CD86 sont des ligands de CD28 et CD152 Figure CD40 Ligand Market Size and Growth Rate of ISF-35 from 2014 to 2026. Figure CD40 Ligand Market Size and Growth Rate of LOAd-700 from 2014 to 2026. Figure CD40 Ligand Market Size and Growth Rate of MEDI-4920 from 2014 to 2026. Figure CD40 Ligand Market Size and Growth Rate of MegaCD40L from 2014 to 202

CD40-ligand stimulates myelopoiesis by regulating flt3

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell. 1993 Jan 29;72(2):291-300. [PubMed:7678782] Spriggs MK, Armitage RJ, Strockbine L, Clifford KN, Macduff BM, Sato TA, Maliszewski CR, Fanslow WC: Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J Exp Med. 1992 Dec 1;176(6):1543-50 CD40 Ligand (CD40L), also known as CD154, gp39, TNFSF5, TRAP (TNF-Related Activation Protein) or TBAM (T-cell B-cell Activating Molecule), is a multifunctional ligand in the TNF superfamily (1-4). Interaction between CD40 and CD40L is critical to the control of thymus-dependent humoral immunity and cell-mediated immune responses (5-10). The major component of the contact-dependent signal. For several years, the primary function of CD40 ligand (CD40L) has been believed to be in regulation of contact-dependent, CD40-CD40L-mediated signals between B- and T-cells, which are essential for the regulation of thymus-dependent (TD) humoral immune responses. Recently, a flurry of reports indicate that CD40 is expressed by variety of cell types other than B-cells that include dendritic cells, follicular dendritic cells, monocytes, macrophages, fibroblasts, and endothelial cells. These. CD40 is a tumor necrosis factor receptor (TNFR) family protein that plays an important role in B cell development. CD154/CD40L is the physiological ligand of CD40. We have determined the crystal structure of the CD40-CD154 complex at 3.5 Å resolution. The binding site of CD40 is located in a crevice formed between two CD154 subunits. Charge. Anti-Human CD40 ligand Therapeutic Antibody (Toralizumab) (CAT#: TAB-876) Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD40 ligand. Toralizumab was a humanized monoclonal antibody and an immunosuppressive drug. Possible indications included treatment of antibody-mediated disorders (immune thrombocytopenic purpura,.

CD40 Ligand, Human RecombinantAnimal Free CAS - Find MSDS or SDS, a COA, data sheets and more information. Les cookies sur notre site . Sur notre site Internet, nous utilisons des cookies (témoins) pour nous aider à vous offrir la meilleure expérience en ligne possible. Si vous poursuivez et acceptez tous les cookies, vous recevrez tous ceux que nous utilisons sur le site. Si vous souhaitez. Soluble CD40 ligand (sCD40L) is a platelet-derived proinflammatory mediator that accumulates during platelet storage. We hypothesized that human polymorpho-nuclear leukocytes (PMNs) express CD40, CD40 ligation rapidly primes PMNs, and sCD40L induces PMN-mediated cytotoxicity of human pulmonary microvascular endothelial cells (HMVECs). Levels of sCD40L were measured in blood components and in. Recombinant Human CD40 Ligand Protein (Met113-Leu261) ECD Biotinylated 10239-H42H-B with a fusion hFc & AVI Tag, is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human CD40 Ligand protein for relevant bioassay and related research ligand de CD40 [Concept NCIt] Concept(s) lié(s) au record. Ligand de CD40 [MeSH Concept] Concepts Supplémentaires MeSH en relation. anticorps monoclonal ABI793 [MeSH Concept Supplémentaire] Liste des qualificatifs affiliables. action des médicaments et substances chimiques [Qualificatif MeSH] administration et posologie [Qualificatif MeSH NCIt definition: CD40 ligand (261 aa, 29 kDa) is encoded by the human CD40LG gene. This protein is involved in both binding to CD40 and the modulation of B-cell function.; Alternative definition: NCI-GLOSS: A substance that is being studied in the treatment of cancer. It binds to certain immune cells and may suppress cancer growth.; NCIt note: Cell surface marker TRAP (CD40 ligand) is a member.

CD40 Ligand-Modified Chimeric Antigen Receptor T Cells

CD40 Ligand, also known as TNFSF, CD154, TRAP, and gp39, is a 34-39 kDa type II transmembrane glycoprotein that belongs to the TNF superfamily (1-3). Mature human CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and an 215 aa extracellular region (4, 5). The extracellular domain of human CD40 Ligand shares 74% and 76% aa sequence identity with mouse and. Recombinant CD40 Ligand (CD40LG) Protéine. Origine: Souris. Commandez ABIN620264

CD40 ligand expression was inhibited by pretreatment of T cells with cyclosporin A. Cyclosporin A analogues inhibited CD40 ligand expression with a potency mirroring the ability of each compound to inhibit calcineurin activity, indicating that calcineurin plays a key role in CD40 ligand gene expression. Cyclosporin A inhibited IL-4-driven CD40 ligand-dependent IgE isotype switching in PBMC but. Interactions between CD40 expressed on macrophages and CD40 ligand expressed on T lymphocytes can be an important signal for optimal macrophage activation. Previous studies have demonstrated that the optimal response against certain intracellular pathogens (e.g., Crytosporidium and Leishmania spp.) by macrophages requires CD40-CD40 ligand interactions

Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice. Response correlates with the absence of an anti-antibody response. J Immunol 1996. 157:3159-3164. View this article via: PubMed Google Scholar. Ma, J, et al. Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with. CD40 binds to a ligand (CD40-L) which is an approximately 35 kDa glycoprotein of 261 aa, a member of the tumor necrosis factor superfamily. The CD40-L gene maps to human chromosome Xq24. This CD40. High Purity&High Activity&Low endotoxin, Biotin-labeled Proteins Availabl CD40 ligand (CD40L), also known as CD154, TRAP, and gp39, is the ligand for the TNF receptor family member CD40 (1-6). CD40L is expressed either as a soluble cytokine or as a homotrimeric transmembrane protein. CD40L primarily expressed on the surface of T-cells, but has also been reported in blood platelets, mast cells, basophils, NK cells, and B-cells. It plays an important role in stimulating B-cell cell proliferation and survival and promotes immunoglobulin class switching and secretion. CD40 Ligand is expressed on stimulated lymphocytes in normal individuals. Interpretive Data. Mutations in the CD40 ligand gene are associated with X-linked hyper IgM (HIGM) syndrome. Analysis of the expression of CD40L on activated T cells assists in the diagnosis of X-linked HIGM syndrome. TLR Disease Association Reference ; TLR2 M. tuberculosis, S. aureus and other gram positive infect; CPT.

CD40 Ligand Monoclonal Antibody - an overview

The CD40 ligand or CD40 pathway is widely recognized for its prominent role in immune regulation and homeostasis. CD40 is a surface antigen expressed on B cells and the CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is difficult for proliferation and isotype switching in the context of a response to a T-celldependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to IgG, IgE and IgA. CD40 Ligand (CD40-L) CD40 Ligand (CD40-L) is a transmembrane protein expressed on T cells, B cells, mast cells, basophils, eosinophils, natural killer cells, macrophages, endothelial cells, vascular smooth muscle cells, and activated platelets. It is also found in plasma as a soluble protein, sCD40-L. As a consequence of CD40-L binding to its receptor (CD40), several inflammatory processes are initiated. Studies have demonstrated elevated CD40-L levels in patients with hypercholesterolemia. CD40-ligand is also known as CD154, the T cell-B cell activating molecule (T-BAM), TRAP or gp39. CD40-ligand is a member of the Tumor Necrosis Factor (TNF) Super Family. Other TNF Super Family. Consequently, CD40 signaling has been associated with pathogenic processes of chronic inflammatory diseases, such as autoimmune diseases, neurodegenerative disorders, graft-versus-host disease, cancer, and atherosclerosis CD40-ligand is a protein expressed on the surface of activated T lymphocytes that mediates T cell helper function. CD40-ligand is also known as CD154, the T cell-B cell activating molecule (T-BAM),..

Frontiers | The Role of Dendritic Cell Maturation in the

Video: CD40LG gene: MedlinePlus Genetic

CD40-ligand is a protein expressed on the surface of activated T lymphocytes that mediates T cell helper function. CD40-ligand is also known as CD154, the T cell-B cell activating molecule (T-BAM), TRAP or gp39. CD40-ligand is a member of the Tumor Necrosis Factor (TNF) Super Family. Other TNF Super Family members have proven to be targets for antagonist mAbs. Licensed mAbs against TNFα. The CD40-CD40 ligand system is one of the body's most potent immune system activators. Activation elicits both antibody and cellular immune responses Because of MEM40, MemVax can be used as a vaccine adjuvant capable of synergistic combination with coronavirus vaccines Memgen's technology could address many challenges facing coronavirus vaccine development: Effectiveness in older. CD40 ligand (CD40L, též CD154) je protein přítomný především na aktivovaných T-lymfocytech, ale v menší míře také na téměř všech ostatních bílých krvinkách i buňkách epitelu, endotelu a hladké svaloviny.. Funkce. Na povrchu T-lymfocytů označovaných jako T H 2 funguje jako kostimulační protein a váže především CD40 na povrchu B-lymfocytů

CD40 ligand (CD154) is the primary ligand for CD40 and is expressed by activated T cells, critical regulators of cellular and humoral immunity. Signaling via CD40 triggers activation of antigen-presenting cells (APC) CD40 ligand (CD40L) is a 33‐kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of resting B cells, immunoglobulin (Ig) secretion from B cells cultured with cytokines and cytokine secretion and tumoricidal activity from monocytes. In this report CD40L is shown to be stimulatory for human T cells, inducing CD25 (p55 IL. CD40 is a member of the tumor necrosis factor superfamily. Together with CD40 ligand, the molecule that binds to it, CD40 is an important contributor to the inflammatory processes that lead to atherosclerosis and thrombosis (clotting). The gene encoding CD40 is on chromosome 20

The CD40/CD40L costimulatory pathway in inflammatory bowel

CD154 (known as CD40L) is the ligand of CD40, a type II transmembrane protein, with a variable molecular weight between 32-39 kDa [6, 7]. CD40L is mainly expressed on activated CD4+ T cells and is a member of TNF superfamily. The human CD40L gene is located on the X chromosome, Xq26.3‑Xq27.1 CD40 ligand (CD40L, also known as CD154) is an important costimulatory molecule found on the T-cell and is critical for the development of immunity. CD40L may provide a novel adjuvant to enhance cytokine and antibody response to RSV, directing a subject's immune response further towards Th1-mediated outcomes rather than a less effective Th2-type response. This Th2-type response has been previously suggested as the cause of previous live-RSV vaccine failures. This technology, appropriately. L'interaction entre CD40 du lymphocyte B activé et le CD40 ligand sur le lymphocyte T auxiliaire est essentielle pour provoquer Auto-immune regulator CD40 /CD40L, LTbR/LTa1b2) L'absence de chacun de ces récepteurs et ligands entraînent chez la souris des défauts d'organisation sont sous la dépendance de signaux fournis notamment par les précurseurs thymiques des lymphocytes via des interactions ligand /. CD40, a member of the tumor necrosis factor (TNF) receptor family, is a transmembrane glycoprotein that is expressed mainly in antigen-presenting cells, including B cells, dendritic cells, and macrophages [ 5 ] CD40 ligand (L) may promote inflammation and thrombus formation, and we hypothesized that CD40L could be involved in the pathogenesis of PAH. Methods and Results— Several significant findings were revealed when examining the possible role of CD40L in PAH

(PDF) CD40 ligand gene and Kawasaki diseaseAllergic Rhinitis, Asthma, and Atherosclerosis in the

CD40-Ligand. Das vom CD40LG Gen kodierte Protein ist der Ligand des CD40 auf den T-Lyphozyten. Die kopplung des CD40 auf den B-Lymphozyten mit dem CD40LG ist für eine reife Immunantwort insbesondere dem Klassenwechsel unerlässlich. Deshalb produzieren Patienten exzessiv das Immunglobulin IgM und zeigen eine erhöhte Infektanfälligkeit. Gentests: Klinisch: Untersuchungsmethoden. CD40-CD40 ligand (CD40L) interactions exert profound effects on immune and non-immune cells.1-3 In a patho-genic setting, deregulation of CD40 signalling has been observed in multiple autoimmune diseases.1-3 Con versely , therapeutic upregulation of the CD40 pathway in cancer might have potent anti-tumour effects. Consequently, the CD40 pathway has long been an attractive ther-apeutic. CD40 Ligand is expressed on the surface of activated T cells. It binds to CD40 on the surface of B cells to initiate immunoglobulin class switching. Mutations in CD40L cause X-Linked Hyper IgM syndrome Type 1. This panel test for the expression of CD40L on activated T cells with 2 antibodies from different clones that bind at different epitopes of the CD40L molecule. It also tests the.

The CD40 ligand (CD40L) is a member of the tumor necrosis factor (TNF) family of proteins and is transiently expressed on the surface of activated T cells. The binding of CD40L to CD40, which is expressed on the surface of B cells, provides a critica.. CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40-L stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40-L has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes CD40-Ligand, or CD154, is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. CD40-Ligand binds and activates the CD40 receptor on antigen-presenting cells. CD40-Ligand stimulates B cell proliferation, immunoglobulin class switching, and antibody secretion

Among other dissimilarities, neoplastic T cells showed coexpression of CD40 (Bp50) and CD40 ligand (gp39, CD154). These results could be corroborated by reverse transcription-PCR, immunohistochemistry, and two-color immunofluorescence staining. Our data suggest that in cutaneous T-cell lymphoma, CD40/CD40 ligand interactions might represent a paracrine loop that is crucial not only in. CD40 is a 48 kDa type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed broadly on antigen-presenting cells (APCs) such as dendritic cells, B cells, macrophages, and monocytes as well as non-immune endothelial cells, basal epithelial cells, and a range of tumors. Upon binding to its ligand CD154, CD40 acts as a costimulatory. CD40 ligand (CD154) is the primary ligand for CD40 and is expressed by activated T cells, which are critical regulators of cellular and humoral immunity. Signaling via CD40 triggers activation of antigen-presenting cells (APC). Agonist CD40 antibodies were found to mimic the signal of CD40 ligand and were capable of substituting for the function of CD4+ helper T cells in murine models of T. CD40 ligand (261 aa, ~29 kDa) is encoded by the human CD40LG gene. This protein is involved in both binding to CD40 and the modulation of B-cell function

CD40 Ligand is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity CD40 Ligand Subject Areas on Research. Objective: Plasma soluble CD40 ligand (sCD40L) is increased during HIV-1 infection, but it is unk

Clustering of CD40 ligand is required for the clustering of its cognate receptor, CD40. A andB, co-incubation of CD40 ligand-positive EL4 T cells with JY B cells results in clustering of CD40 on JY B cells (A). Cells were stained with Cy3-coupled anti-CD40 5C3 antibodies. No cross-reaction with the T cells was observed. Displayed is a representative fluorescence microphotograph from four. CD40; T cell; dendritic cell; pancreatic cancer; The discovery and elucidation of pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs, respectively) revolutionized the understanding of mechanisms by which activation of innate immunity converts to the triggering of robust adaptive responses ().At a cellular level, these molecular ligands connect dendritic cells (DCs. casSAR Dugability of P27548 | Cd40lg | CD40 ligand - Also known as CD40L_MOUSE, Cd40lg, Cd40l, Tnfsf5. Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and. CD40 Ligand CD40-ligand Svensk definition. Ett höljeglykoprotein och differentieringsantigen som uttrycks på ytan av T-celler. Det binder till CD40 (CD40 antigen) på B-celler och framkallar B-cellsproliferation. Mutation i detta protein ger up phov till X-bundet hyper-IgM-syndrom (hypergammaglobulinemi). Engelsk definition . A membrane glycoprotein and differentiation antigen expressed on. Anti bovine CD40 product information; Anti bovine CD40 is available 2 times from supplier kingfisherbiotech at Gentaur.com shop. Filters. Technique. Supplier. Species. Label. Isotype. Host. Tissue . Virus. Disease. Anti bovine CD40. Anti bovine CD40 is available 2 times from Kingfisherbiotech labs KP1209B-100 | Anti-bovine CD40 Ligand PAb size: 100 ug | 536.49 USD Catalog number KP1209B-100. CD40 and CD40 ligand (CD40L) interactions play a critical role in regulating T-cell-dependent humoral immunity, the threshold for negative selection in the thymus and the induction of peripheral tolerance

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